|
KMID : 0604520050310030219
|
|
Journal of the Society of Cosmetic Scientists of Korea
2005 Volume.31 No. 3 p.219 ~ p.226
|
|
|
The Effects and Mechanisms of Glycolic Acid on the UV-induced Skin Cell Proliferation
|
|
Hong Jin-Tae
Pyo Hyeong-Bae
Lee Hwa-Jung
Lee Choong-Woo
Yoon Yeo-Pyo
Ahn Kwang-Soo
Cho Chan-Hwi
Hong Ki-Young
|
|
|
Abstract
|
|
|
|
Glycolic acid, an alpha-hydroxy acid derived from fruit and milk sugars, has been commonly used as a cosmetic ingredient since it was known to have photo-protective, anti-inflammatory effects, and anti-oxidant effect in UV-irradiated skin. However, little has been know about the functional role of glycolic acid on UV-induced skin cell proliferation. It was previously found that glycolic acid inhibited UV-induced skin tumor development in hairless mouse. As a possible mechanism of glycolic acid on the UV-induced skin tumor development, the ability of glycolic acid to inhibit the UVB-induced cell growth and possible mechanisms were investigated. Glycolic acid treatment attenuated the UV-induced cell proliferation and apoptotic cell death in the skin. In vitro study, glycolic acid inhibited the UVB-induced cell growth and apoptotic death through inhibiting caspase-3 activity. These results suggest that glycolic acid may exert the Inhibitory effect on the UVB-induced skin tumor development by regulating cell growth and apoptotic cell death.
|
|
|
KEYWORD
|
|
|
glycolic acid, UV, cell proliferation, apoptosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|